Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity

Farmacia

Wataru Kadowaki, 1 ,† Ryo Miyata, 1 ,† Sayaka Mizuno, 1 Misa Fujinami, 2 Yoshizumi Sato, 2 and Shigenori Kumazawa 1 , ∗ 1 Graduate School of Integrated Pharmaceutical and Nutritional Sciences, University of Shizuoka, Shizuoka, Japan; and 2 Kisho Corporation, Tokyo, Japan ∗Correspondence: Shigenori Kumazawa, kumazawa@u-shizuoka-ken.ac.jp † The first two authors contributed equally to this work. Bioscience, Biotechnology, and Biochemistry , 2023, Vol. 87, No. 7, 683-687

ABSTRACT

Calendula officinalis is a medicinal plant in the Asteraceae family, and it has a broad range of biological activities. In this study, we focused on the roots of C. officinalis , which have remarkable anti-inflammatory properties. By using a bioassay-guided fractionation approach, prenylated acetophenones 1 and 2 —of which 1 was previously unknown—were isolated, and their structures were determined by spectroscopic analysis. Both compounds decreased lipopolysaccharide-stimulated NO production in J774.1 cells. This study could lead to the use of the Calendula roots as a natural source of inflammatory mediators

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Prenylated acetophenones from the roots of Calendula officinalis and their anti-inflammatory activity

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